中文摘要：

背景神经调节蛋白1（neuregulin1，NRGl）是一类表皮生长因子家族的成员，其在神经元及胶质细胞的生长发育及迁移等方面起着关键作用，但在成熟的神经系统及慢性疼痛中的作用却不甚清楚。目的阐述NRGl介导慢性疼痛的最新研究进展，并对其在疼痛中作用的研究提出展望。内容简述NRGl及其受体的功能以及在疼痛领域中作用的研究。趋向NRGl通过复杂的机制参与了神经病理性疼痛的发生发展，有望为临床提供新的治疗靶点。

英文摘要：

Background Neureguhnl （NRG1） is a member of family of epidermal growth factors, which play an important effect in the development and immigration of neuron and glial cells, but not clear in the mature nerve system and chronic pain. Objective This article reviewed the newest research about NRG1 in the chronic pain and looked forward to the value of NRG1 in the chronic pain in the future. Content The text states the function and role of NRG1 and its receptors in the chronic pain and neuropathic pain. Trend NRG1 has a great role in the generation and development of the chronic pain through complex mechanisms and will offer a new target point for the treatment of chronic pain.