Synthesis of 1-Aryl-1 H-indazoles via a Ligand-Free Copper- Catalyzed Intramolecular Amination Reaction
- ISSN号:1001-604X
- 期刊名称:《中国化学:英文版》
- 分类:TQ226.31[化学工程—有机化工] TB333[一般工业技术—材料科学与工程]
- 作者机构:[1]Key Laboratory of Regenerative Biology and Institue of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China, [2]Jiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, Jiangsu 210009, China
- 相关基金:Project supported by the National Natural Science Foundation of China'(Nol 21002102), and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (No. 10184).
关键词:
反应合成, 分子内, 催化胺化, Ullmann偶合反应, 配体, 芳基, 无氧铜, 铜催化, copper, amination, ligand free
中文摘要:
从 o-halogenated 芳基醛或酉同类和芳基肼的 1-aryl-1-H-indazoles 的一般合成被描述。这个协议包括了一个分子间的冷凝作用和联合反应的一种 ligand 免费的催化铜的 intramolecular Ullmann 类型。这个方法被用于大量底层在好收益生产 indazole 产品。
英文摘要:
A general synthesis of 1-aryl-l-H-indazoles from o-halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand-free copper-catalyzed intramolecular Ullmann-type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.