中文摘要：

近年来，硅材料微电极阵列发展迅速，为研究大脑神经细胞活动的时空特性提供了理想的手段．考察了线性硅材料微电极阵列在神经细胞电位检测中的稳定性，以及对于单细胞动作电位检测的有效性．实验结果表明，在麻醉大鼠海马CA1区场电位记录中，上下移动记录微电极200μm，对于正向和反向诱发电位的记录几乎没有影响，说明，线性微电极阵列对于神经细胞的损伤很小，检测性能稳定．电极阵列上处于细胞胞体层的测量点可以有效地记录到CA1神经细胞的动作电位发放，同一记录点上可以清楚地分辨出数个不同神经细胞的发放电位．实验结果显示了硅电极阵列操作简便、检测信号稳定和获取信息多等特点，对于开展微电极阵列应用研究的工作人员具有借鉴作用．

英文摘要：

The rapid development of silicon microelectrode arrays provides an ideal means for the study of spatio-temporal features of neuronal activity in the brain. The stability of the linear silicon electrode array （LSEA） in recording neuronal potentials and its validity in recording unit activity are investigated. The experimental results showed that during the recording of field potentials in the hippocampal CA1 region of anesthetized rats, upward and downward movements of the recording probe for a distance of 200 μm did not affect the orthordromic and antidromic evoked potentials significantly. The data indicated that the probe movements caused very small damage to the neurons, and the recording was stable. The contact sites that located in the pyramidal cell layer acquired CA1 neuronal unit activity validly. Different types of unit activity from independent neurons were easily distinguished in epochs of recording from a same recording site. These results demonstrated the features of the LSEA, including the facility of probe manipulation, the stability of recording and the abundance of data acquirement. The data will be helpful to the researchers involved in the application ofmicroelectrode array for neuroscience researches.