中文摘要：

背景瞬时感受器电位香草酸受体l（transientreceptorpotentialvanilloid1，TRPV1）是瞬时感受器电位超家族的成员之一，主要表达在初级传人感觉神经元上，是一种非选择性的阳离子通道。近几年对TRPV1的研究取得了较大进展。目的TRPV1作为一种与痛觉密切相关的离子通道型受体，在神经病理性疼痛中发挥着重要作用。综述TRPV1在神经病理性疼痛方面的研究进展。内容TRPV1的结构与分布研究进展，TRPV1在神经损伤后发生表达的变化，以及降低TRPV1的功能后对神经病理性疼痛的影响。趋向对TRPV1与神经病理性疼痛的深入研究将为开发新一代镇痛药物提供理论依据。

英文摘要：

Background Transient receptor potential vanilloid 1 （TRPV1）, one member of the superfamily of the transient receptor potential, is a non-selective cation channel, mainly expressing in the primary afferent fibers of sensory neurons. Objective Acting as an ion channel receptor, TRPV1 plays a critical role in neuropathic pain. Progress in the study of TRPV~ in neuropathic pain was reviewed. Content Progress in the structure and expressing profile, the alteration of expressing following nerve injury, and the effect of inhibitors on neuropathic pain were reviewed. Trend Progress in the study of TRPVt and neuropathic pain may provide theoretical foundation for the discovery of new analgesia agents.