引言 超临界流体掺杂是近年发展起来的绿色化工高新技术,诸如超临界CO2中聚合物染色、药物缓释体系或纳米微胶囊等都属于典型的超临界掺杂过程。常见的药物分子如布洛芬、酮洛芬等,已被证实可随高压CO2在聚合物中包合。
A high-pressure quartz crystal microbalance(QCM)apparatus was developed to investigate the absorption of carbon dioxide in two glassy polymer films—polystyrene(PS)and polyvinylpyrrolidone(PVP)at 40℃ and pressure up to 9.0 MPa.PVP was shown to have better CO2 absorption and chosen as the representative for supercritical impregnation of two model drugs—o-aminobenzoic acid and ibuprofen at 40℃ and pressure up to 8.0 MPa.It was found that the two impregnants were embedded into the polymer with a partition coefficient as high as 104 order of magnitude.Since the sub-microweighing technique established and utilized in this study was simple,convenient and accurate,it was believed that the technique could have wide and effective applications in supercritical impregnation processes.