中文摘要：

规范瞬时受体电位离子通道（canonical transient receptor potential channel,TRPC）对钠和钙离子具有通透性。各种TRPC同聚体或异聚体复合物调节着血管中平滑肌和内皮细胞的诸多生理功能,它们的异常表达通常与高血压、内皮通透性增加等疾病的发生相关,是导致血管重构的重要分子基础。因此,研究TRPC在血管重构过程中的作用,能够为疾病的治疗提供新思路。

英文摘要：

Transient receptor potential channel （TRPC） family, which functions as a non-selective cation channel, allows the entry of Na＋ and Ca2＋ ions into the cells. Different homomeric or heteromeric TRPC channels regulate various physiological functions in smooth muscle and endothelial cells of blood vessel. Abnormal TRPC expressions, which is the important underlying molecular mechanism of vascular remodeling,may be responsible for pathophysiological processes of hypertension as well as increased endothelial permeability. Thus,investigating the roles of TRPC ion channels in the pathogenesis of vascular remodeling provides new therapeutic approach to the related disease.