中文摘要：

Epstein-Barr 病毒(EBV ) 编码了潜伏的膜蛋白质 1 (LMP1 ) 被知道了在鼻咽的癌(NPC ) 在潜伏的感染期间有 oncogenic 性质。我们的研究在 NPC 集中了于 LMP1 的角色，并且证明 LMP1 触发表明小径的 NF-B， AP-1 和 STAT。惊人地， LMP1 被发现调停在 c6 月和 JunB 之间的新 heterodimer 的形成。另外，我们鉴别了 JAK/STAT 和 PI-PLC-PKC 激活通过 upregulating 由 LMP1 被触发 JAK3 的表示并且提高 STAT 的 phosphorylation。这些发信号的串联的组成的激活解释 LMP1 的能力导致如此的一个多样的数组词法并且 phenotypic 在房间完成并且提供 LMP1 怎么可以导致房间转变， multihit 在下游的戏在指向了基因的卓见一个必要角色。LMP1 触发的所有发信号的串联最终导致房间周期的混乱：G1/S 阶段的加速和 G2/M 阶段的拘捕。我们也发现 LMP1 导致了 hTERT 的表示并且支持了房间不减。重要地，由干涉物理细胞内部的信号 transduction 小径并且扰乱房间周期的前进， LMP1，重要 oncoprotein 由 EBV 编码了，被认为是在 NPC 的致病的一个关键调节的人。介入的 LMP1 发信号能是有希望的策略指向 NPC 的恶意的显型。

英文摘要：

Epstein-Barr virus （EBV）-encoded latent membrane protein 1 （LMPI） has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma （NPC）. Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STATo The constitutive activation of these signaling cascades explains LMP1＇s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle： the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. Cellular ＆ Molecular Immunology.