中文摘要：

目的：探讨腹部推拿对便秘型肠易激综合征患者（IBS）结肠组织中脑肠肽含量的影响。方法：60例患者随机分成腹部推拿组、安慰剂对照组两组,每组各30例,15 d为1个疗程。采用免疫组织化学技术,检测便秘型肠易激综合征患者结肠组织中治疗前后降钙素基因相关肽（CGRP）、P物质（SP）、血管活性肠肽（VIP）、胆囊收缩素（CCK）等脑肠肽的含量变化。结果：腹部推拿组患者治疗后结肠组织中CGRP、SP、VIP、CCK各指标均较治疗前明显下降,而安慰剂对照组治疗前后无明显差异,腹部推拿组患者上述指标优于安慰剂对照组。结论：腹部推拿可能通过改善便秘型肠易激综合征患者中枢神经环路致敏化和脑肠肽表达,从而有效调控脑肠互动途径以治疗便秘型肠易激综合征。

英文摘要：

Objective ： To discuss the effect of abdominal massage on the amount of brain intestinal peptide in constipation type of IBS patients. Method： A total of 60 patients were randomly separated into two groups ： abdominal group and control group, with 30 patients in each group. After 15 days treatment, we adopted immunohistoehemical technique to detect the changes of CGRP, SP, VIP and CCK. Results ： After the treatment, the amount of CGRP, SP, VIP and CCK in abdominal massage group decreased compared with those before while the control group showed no significant differences. The abdominal massage group showed a better effect compared with the control group. Conclusion ： Abdominal massage might effectively regulate the interaction pathway of brain and intestine through improving the sensitization of central neural circuit and expression of brain intestinal peptide to treat the constipation type of IBS.