中文摘要：

目的研究趋化因子γ干扰素诱导蛋白10（IP-10）在病理性瘢痕中的表达,探讨其在病理性瘢痕发病机制中的作用。方法应用免疫组化技术检测趋化因子IP-10在28例瘢痕疙瘩（K组）、34例增生性瘢痕（HS组）及20例正常皮肤（N组）中的表达,并进行统计学分析。结果IP-10在K组及HS组中均呈高表达,与N组比较差异均具有统计学意义（P〈0.01）,但K组与HS组之间差异无统计学意义（P〉0.05）。结论IP-10可能通过趋化T淋巴细胞定向迁移,引发一系列免疫炎性反应,从而促进病理性瘢痕的形成。

英文摘要：

Objective To explore the expression of 10 kDa interferon-gamma-induced protein （IP-10）in pathological scar and its role in the pathogenesis of pathological scar. Methods Immunohistochemistry was performed to detect the expression and distribution of IP-10 in 28 patients with keloid（group K）,34 patients with hypertrophic scar（group HS）,and 20 normal controls（group N）. The data were collected and analyzed statistically. Results The expression of IP-10 was significantly higher in groups K and HS than in group N （P 0.01）, but no significant difference in the expression of IP-10 was found between groups K and HS. Conclusion IP-10 may enhance the formation of pathological scar by attracting T lymphocytes and inducing immune/inflammatory response.