中文摘要：

目的：探讨前列腺癌中肿瘤血管生成与凝血酶敏感蛋白-1（TSP-1）表达的相关性。方法：采用免疫组织化学法检测22例前列腺癌中微血管密度（MVD）值和TSP-1的表达。结果：前列腺癌中TSP-1阳性表达率为72．7％（16／22），绝大多数表达位于肿瘤细胞的胞浆中，少数表达位于肿瘤细胞外基质。在22例前列腺癌组织中平均MVD为71．21±31．14／100倍视野，具有TSP-1强表迭的肿瘤组织中显示MVD值较高．TSP-1的免疫活性与微血管密度间呈显著相关性（r=0．54，P=0．009）。结论：TSP-1在前列腺癌组织中呈高表达与前列腺癌的血管生成相关，有促进前列腺癌中血管生长的作用，并参与前列腺癌血管基因的表迭。

英文摘要：

Objective： To observe the expression of thrombospondin-1 （TSP-1） separately in prostatic carcinoma, and its relationship with the angiogenesis. Methods： The expression of TSP-1 and the value of microvessel density （MVD） were studied in 22 prostatic carcinoma patients using immunohistochemistry. Results： Positive expression of TSP-1 protein detected inl6 of the 22 （72.7%） cases. Most positive staining for TSP-1 was seen in the cytoplasm of the cancer cells, some was in the extracellular matrix. The mean MVD in 22 cases with prostatic carcinoma was 71.21±31.14 vessels per 100 field of vision. Tumors with a high expression of TSP-1 showed a high value of MVD and the correlation between TSP-1 immunocompetence and microvessel density was highly significant （r=0.54, P=0.009）. Conclusions： The TSP-1 is strongly expressed in most prostatic carcinoma and were associated with neovascularization-1 expression might TSP-1 is likely to contribute to the extensive neovascularization and increased TSP- participate in angiogenic phenotype in prostatic carcinoma.