(R)-2-羟基-4-苯基丁酸乙酯是血管紧张素转化酶抑制剂类(ACEI)药物的重要中间体.综述了其合成方法,重点介绍了最新的高效合成方法的研究进展.
(R)-2-Hydroxy-4-phenylbutyrate is a key intermediate for the synthesis of angiotensin-converting enzyme inhibitors(ACEI).The review will cover its synthetic methods,and mainly focus on the recent progress in efficient synthesis.