以溴十一酸、苄硫醇、生物素和长醚链二胺为原料,通过活化酯法,设计并合成了一种新型长链含巯基的生物素衍生物——11-巯基十一酸-(8-生物素酰胺基-3,6-二氧辛基)酰胺,其结构经1H NMR和IR表征。
A novel long chain biotin containing mercapto derivative,11-mercaptoundecanoic-(8-biotinoylamido-3,6-dioxaoctyl) amide,was designed and synthesized by activation ester method from bromine eleven acid,benzyl mercaptan,biotin and diamine with ether linkage.The structure was confirmed by 1H NMR and IR.