中文摘要：

肿瘤细胞多药耐药性（multidmg resistance，MDR）的产生是临床上导致肿瘤化疗失败的主要原因之一，因此寻找高效低毒的MDR逆转剂已成为肿瘤药物开发领域的热点。MDR的作用机制主要包括P-糖蛋白、多药耐药相关蛋白、乳腺癌耐药蛋白、肺耐药相关蛋白等等。多药耐药逆转剂包括钙离子通道阻滞剂、维拉帕米及其衍生物等等。本文主要介绍了MDR的作用机制以及肿瘤多药耐药逆转剂的研究进展。

英文摘要：

Multidrug resistance （MDR） is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors. Searching for highly effective and lowly toxic reversal agents for MDR is a hot field in regard to cancer drug development. The mechanisms of MDR mainly include P-glycoprotein, muhidrugresistance-associated protein, breast cancer resistance protein, lung resistant-related protein, etc.. MDR reversal agents include calcium channel blockers, Verapam and its derivative, etc.. This paper mainly introduces the mechanisms of MDR and the development of MDR reversal agents.