中文摘要：

目的采用静息态功能磁共振（rs-fMRI）区域局部一致性（ReHo）技术,观察复发缓解型多发性硬化（RRMS）患者脑局部ReHo值。方法收集19例RRMS患者（RRMS组）与19名年龄、性别相匹配的健康对照者（对照组）行rsfMR和常规MR检查。分别提取两组左、右侧运动相关脑区ReHo值行两样本t检验分析,对RRMS组双侧运动相关脑区ReHo值与患者EDSS评分行相关性分析。结果与正常对照组相比,RRMS患者双侧运动相关脑区ReHo值降低（P〈0.05,经AlphaSim校正,体素〉20）,患者双侧运动相关脑区ReHo值与EDSS评分均呈负相关（右侧：r=-0.819,P〈0.05;左侧：r=-0.871,P〈0.05）。结论 RRMS患者运动相关脑区神经元活动一致性存在减低改变,这种改变可能是患者运动功障碍形成的相关因素之一。

英文摘要：

Objective To observe the regional homogeneity（ReHo）value of motor-related cortex in patients with relapsing-remitting multiple sclerosis（RRMS）using resting state functional magnetic resonance imaging（rs-fMRI）.MethodsNineteen patients with RRMS（RRMS group）and 19gender-and age-matched healthy controls（control group）underwent rs-fMRI and conventional MRI.Bilateral motor-related cortex were selected as ROIs to measure ReHo values and were analyzed by two sample t test,Correlation analysis was performed between the ReHo values and expended disability status scale（EDSS）.Results Compared with control group,the ReHo values of motor-related cortex in RRMS group decreased（P〈0.05,AlphaSimcorrection,voxel〉20）.The bilateral ReHo values showed negative correlation with EDSS（right r=-0.819,P〈0.05,left r=-0.871,P〈0.05）.Conclusion ReHo values of motor-related cortex in RRMS patients have been decreased,which may be one of the relevant factors related to disability.