目的检测变应性鼻炎(AR)患者血清25-羟维生素D的含量,明确AR与血清25-羟维生素D的相关性。方法收集2015年5月-11月新疆医科大学第一附属医院就诊的60例AR患者(AR组)的临床资料,同时选取60例健康体检者(对照组),采用化学发光法检测其血清25-羟维生素D值的浓度。结果 AR组的25-羟维生素D浓度值[(55.7±8.94)nmol/L]明显低于对照组[(80.65±12.06)nmol/L],差异有统计学意义(P〈0.05),AR组25-羟维生素D缺乏与不足所占的比例[8.3%(5/60)、91.7%(55/60)]明显高于对照组[71.7%(43/60)、28.3%(17/60)],差异有统计学意义(P〈0.05),AR患者中-重度组25-羟维生素D的浓度值[(49.81±4.48)nmol/L]明显低于轻度组[(60.86±8.71)nmol/L],差异有统计学意义(P〈0.05)。结论 AR与25-羟维生素D有关,AR患者25-羟维生素D的含量较正常人有所降低,且AR病情越重,25-羟维生素D的含量越低。
Objective To study the content of 25-hydroxyvitamin D in patients with allergic rhinitis(AR),and to analyze the correlation between AR and 25-hydroxyvitamin D.Methods 60 cases of AR patients hospitalized from May 2015 to November 2015 in the First Affiliated Hospital of Xinjiang Medical University were selected as the AR group,and 60 healthy subjects were selected as control group,and the chemiluminescence method was used to test the content of the 25-hydroxyvitamin D.Results The concentration of 25-hydroxyvitamin D in AR group[(55.7±8.94)nmol/L]was shown to be significantly lower than that in the control group[(80.65±12.06)nmol/L](P〈0.05).The 25-hydroxyvitamin D level of AR group,the lack and deficiency of the number[8.3%(5/60),91.7%(55/60)]was found to be significantly higher than the control group[71.7%(43/60),28.3%(17/60)](P〈0.05).Concentration of 25-hydroxyvitamin D in moderate to severe group [(49.81±4.48)nmol/L]was significantly lower than that of mild group[(60.86±8.71)nmol/L](P〈0.05).Conclusion There was correlation existed between AR and 25-hydroxyvitamin D.Content of 25-hydroxyvitamin D in AR was found to be markedly lower than that in the normal control,indicating that the more serious the AR condition,the lower the content of 25-hydroxyvitamin D will be.