中文摘要：

糖尿病肾病是多因素引起的复杂性疾病，近年研究发现炎症反应参与了该病的发生与发展。单核细胞趋化蛋白-1是趋化因子CC亚家族的一员，在募集巨噬细胞等炎性细胞参与炎症反应中扮演着重要的角色。其趋化单核巨噬细胞于糖尿病肾组织中，可介导溶酶体释放，产生氧自由基，促进单核臣噬细胞表达β1-转化生长因子（transforming growth factor β1，TGF—β1），而广泛浸润巨噬细胞加剧了肾小球基底膜增厚、细胞外基质堆积，进而发展为肾小球硬化和间质纤维化。深入研究单核细胞趋化蛋白-1在糖尿病肾病中的作用，可望为糖尿病肾病的预防和治疗提供新的思路和途径。

英文摘要：

Diabetic nephropathy （DN） is a complicated disorder induced by multiple factors. Inflammation has been reported to be involved in the progression of DN. Monocyte chemoattractant protein 1 （MCP-1）, one of the CC chemokine subfamily, plays a crucial role in the recruitment of inflammatory cells such as macrophage, and participates in the inflammatory reactions. The recruitment of mononuclear macrophage in nephridial tissue could mediate the generation of oxyradical via lysosome release, and promote the expression of tumor growth factor-β1 （TGF-β1） from macrophages. The extensively infiltrated macrophages promote the thickening of glomerular basement membrane （GBM） and the accumulating of extracellular matrix （ECM）, which resulted in glomerular sclerosis （GS） and interstitial fibrosis. Further investigations of the role of MCP- 1 in DN will shed light on the prevention and therapy of DN.