目的:研究通城移植毛喉鞘蕊花全草的化学成分。方法:利用硅胶柱色谱、制备薄层色谱和ToyopearlHW-40F凝胶渗透进行分离、纯化。根据理化性质和现代波谱技术并辅以化学方法进行结构鉴定。结果:从通城移植毛喉鞘蕊花中分离得到7个化合物,分别鉴定为:羽扇豆醇(1)、齐墩果酸(2)、熊果醇(3)、β-谷甾醇(4)、colonicacid(5)、去甲基柳杉树脂酚(6)、coleolic acid(7)。抗肿瘤实验结果表明化合物1、2、6、7均具有抗肿瘤活性。结论:化合物1、3为首次从该属植物中得到;化合物1为首次从该植物中发现的抗肿瘤活性成分。
Objective:To study the chemical constituents of Coleus forskohlii.Methods:Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F.Compounds were identified and elucidated by spectral and chemical methods.Results:Seven compounds were obtained from ethyl acetate extract fraction.Their structures were identified as lupeol(1),oleanolic acid(2),uvalo(3),β-sitosterol(4),colonic acid(5),demethylcryptojaponol(6),coleolic acid(7).Compounds 1,2,6,7 showed obviously antitumor activity.Conclusion:Compound 1 and 3 are isolated from the genus for the first time.Moreover,compound 1 is firstly found to have antitumor activity from the plants.