中文摘要：

实验于2007-10／2008—07在天津医科大学生物医学工程系超声医学实验室完成。依据森田长吉等人提出的非线性传播的时域有限差分仿真方法，结合生物热传导方程，仿真计算高强度聚焦超声靶区温度的分布。结果显示有血管时聚焦区域内血管处的温升明显低于无血管时周边组织的温升；随着血管直径的增加，血管周边组织的最大温升降低，60℃以上的可治疗区域在减小。血管直径大小对血管周围组织的温升影响很大，在高强度聚焦超声肿瘤治疗时，应该考虑因治疗靶区不同管径血管对高强度聚焦超声温升的影响而导致不同的治疗效果。

英文摘要：

The experiment was performed at the Laboratory of Ultrasonic Medicine, Department of Biomedical Engineering, Tianjin Medical University between October 2007 and July 2008. Finite difference time domain method which was proposed by Morita to simulate nonlinear ultrasound transmission was applied together with bio-heat-transfers-equation to simulate temperature distribution in the focal region. The results show that when there was a blood vessel in tissue, the blood vessel temperature rise was lower than the surrounding tissue temperature rise. The highest temperature in the surrounding tissue and the focal region above 60℃ were decreased with increasing vessel diameter. The blood vessel diameters lead to great changes of temperature distribution. We should consider the influence of blood vessel diameters during high intensity focused ultrasound therapy to destroy tumors.