中文摘要：

目的研究中国大陆人群PTCH基因多态性与散发性牙源性角化囊性瘤(KCOT)易感性的关系。方法提取64例散发性牙源性角化囊性瘤患者和75例正常对照人群外周血基因组DNA,采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)方法分析PTCH基因exon183141T>G位点的单核苷酸多态性(SNP),采用χ2检验进行两组之间基因型、等位基因分布差异的比较。结果散发性牙源性角化囊性瘤中PTCH基因exon183141T>G位点,TT基因型与T等位基因的分布频率均较正常对照人群显著降低(P<0.05)。结论PTCH基因exon183141T>G位点的单核苷酸多态性可能与中国大陆人群散发性牙源性角化囊性瘤易感性有关。

英文摘要：

Objective To screen polymorphisms in exon183141T>G of PTCH gene and to detect whether this polymorphic site was associated with sporadic keratocystic odontogenic tumor(KCOT).Methods Sixty-four patients with KCOT and seventy-five healthy controls were recruited for the study with informed consent.Genomic DNAs were recruited for the study with informed consent.Genomic DNAs were obtained from peripheral blood of KCOT patients and healthy controls.The PCR-based restriction fragment length polymorphism analys...