中文摘要：

目的 探讨磁敏感加权成像（susceptibility-weighted imaging, SWI）Phase图在各期脑梗死的变化规律及其临床应用价值.方法 对65例脑梗死各期患者进行SWI及随诊检查,超急性期（〈6 h）9例,急性期（7～24 h）20例,亚急性期（1.5～7 d）21例,稳定期（8～14 d）5例,慢性期（〉15 d）10例.观察各期脑梗死SWI Phase图上的表现,分别测量最大层面梗死灶受累白质区及对侧相应部位的Phase均值;另外,选取健康志愿者65例进行SWI检查,测量大脑白质区的Phase均值,并进行统计学分析.结果 （1）超急性期及急性期脑的梗死组织的相位值均较对侧健康志愿者脑白质区（HVWM）明显增高,进入亚急性期,相位值较对侧略低,在稳定期和慢性期较对侧明显降低.各期患侧与健侧相位平均值行配对Wilcoxon秩和检验,在超急性期、急性期、稳定期和慢性期两者有显著差别（P〈0.001）,亚急性期,稍有差异（P=0.04）;（2）脑梗死各期病变区平均相位值随着发病时间的延长,逐渐下降,到慢性期最低,梗死区的相位值与发病时间具有显著负相关性（r=-0.990,P=0.001）.结论 利用SWI Phase图可对脑梗死的分期进行评估诊断.

英文摘要：

Objective To investigate clinical application of MR susceptibility--weighted imaging（SWI） phase image in diagnosing cerebral infarction. Methods 65 patients with cerebral infarction underwent conventional MRI and SWI,including 9 cases of hyper- acute infarction （%6 hours）, 20 cases of acute infarction （7-24 hours）, 21 cases of subacute infarction （1.5-7 days）, 5 cases of stable stage （8-14 days）, and 10 cases of chronic infarction （〉15 days）. Furthermore, 65 healthy volunteers were also undergone the same MR examination. Phase values of the infarction and the contralateral and healthy volunteers white matter （HVWM） were measured. The average phase values among the ischemic lesions,the contralateral areas and the HVWMs were compared by Wilcoxon. Results （1） The phase values of hyperacute and acute infarcts were significantly higher than those of eontralateral HVWM （P %0. 001） . However , in comparison with contralateral HVWM , the phase values were slight decreased in subacute infarction（P= 0.04） and significantly decreased in chronic stage（P%0. 001）. （2） With the time prolonged, the average phase values of the ischemie lesion gradually decreased and reached the lowest level in the chronic stage. There was a significant negative correlation between phase values and the time after cerebral infarction （r=-0. 990, P= 0. 001）. Conclusion SWI is useful in staging of cerebral infarction.