中文摘要：

人诱导多能干细胞具有自我更新和分化的多潜能性,其诱导分化的肝样细胞可应用于药物发现、筛选以及药物肝毒性评价研究。药物性肝损伤是导致上市药物被召回和药物研发失败的主要原因之一。临床前动物实验因其种属差异等方面的不足导致药物临床研究失败,浪费了大量人力物力。本文全面总结了人诱导多能干细胞诱导分化的肝细胞在药物肝毒性评价中的研究应用,希望有助于在药物研发过程中准确把握肝毒性,保证人体用药安全。

英文摘要：

Human induced pluripotent stem cells（hi PSCs）possess self-renewing potency and pluripotency and can differentiate into virtually any somatic cell type,such as hepatocytes. The hi PSCsderived hepatocyte-like cells（hi PSCs-derived HLCs）can be used in drug discovery,screening and drug induced hepatotoxicity assessment. Drug-induced liver injury is one of the main causes of drug withdrawals or failure of drug development. Due to species differences in hepatocellular function,unrepresentative results of preclinical animal experiments may lead to the failure of drug development and the waste of human effort and financial resources. This review describes the progress of hi PSCsderived HLCs in drug-induced hepatotoxicity evaluation in the hope of helping to find out more about the liver toxicity in the process of drug development and ensure the safety of human drugs.