中文摘要：

目的：观察二苯乙烯苷（TSG）对小鼠肝微粒体细胞色素P450（CYP）的影响。方法将昆明种雄性小鼠分为空白组、TSG低剂量组和TSG高剂量组，TSG灌胃3、5、7 d后分别麻醉处死小鼠，取肝脏通过荧光实时逆转录聚合酶链反应（real time RT-PCR）检测小鼠肝脏组织 CYP 相关基因 mRNA 的表达。结果 TSG 作用第3、5、7天时均能够抑制 CYP1A2和CYP3A4 mRNA表达；TSG呈时间依赖性的增加CYP2E1 mRNA 表达；TSG作用7 d能够显著抑制CYP4A14 mRNA表达。此外，TSG对CYP2B10、3A11和3A25 mRNA表达无显著性影响。结论 TSG对CYP1A2、CYP2E1、CYP3A4和CYP4A14有显著影响，对CYP2B10、3A11和3A25无明显作用。

英文摘要：

Objective To investigate the effects of tetrahydroxystilbene glucoside （TSG） on cytochrome P450（CYP） in mouse livers .Methods Kunming male mice were divided into the blank ,low dose and the high dose of TSG groups .3 ,5 and 7 after intra-gastrical administration of TSG ,mice were sacrificed and the mRNA expressions of CYP isoenzymes in mouse livers were measured by real time reverse transcription-polymerase chain reaction（RT-PCR） ,respectively .Results TSG significantly inhibited CYP1A2 and CYP 3A4 mRNA expressions at 3th ,5th and 7th day after treatment .TSG time-dependently increased CYP2E1 mRNA expres-sion .TSG inhibited CYP4A14 mRNA expression at 7th day after treatment .Moreover ,TSG had no significant effects on CYP2B10 , CYP3A11 and CYP3A25 mRNA expressions .Conclusion TSG has significant effects on CYP1A2 ,CYP2E1 ,CYP3A4 and CYP4A14 mRNA expressions but no significant effects on CYP2B10 ,CYP3A11 and CYP3A25 mRNA expressions .