中文摘要：

对纵向数据的线性混合效应模型，用Fisher得分法得到了参数的M估计（稳健估计），给出了其渐近性质，研究了M估计下模型的自相关性和随机效应存在性检验问题，得到了检验的Score统计量，并通过葡萄糖数据的实例进行了分析论证．

英文摘要：

In this paper, the Fisher scoring method is applied to get M-estimator（robust esti- mator）in the mixed effects linear model for longitudinal data. And its asymptotic property is given later. Then tests for autocorrelation and presence of random effects in the models are studied based on M-estimation. The score test statistics are obtained and illustrated by the grape sugar data example.