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A parallel approach to direct resolution of albuterol
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：S859.84[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] TP273[自动化与计算机技术—控制科学与工程;自动化与计算机技术—检测技术与自动化装置]
  • 作者机构：[1]National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
  • 相关基金：This paper is dedicated to Professor LIU YouCheng on the occasion of his 90th birthday. This work was supported by the National Natural Science Foundation of China （29790125, 29972039 and 20025205）.
作者： ZHONG QingLin PENG XiaoHua WU TongFei FU FangMin CUI Xin ZHU Jin DENG JinGen[1]
关键词： 沙丁胺醇, 并行方式, 直接解, 选择试剂, Excel, RAC, 脂肪酸, 酒石酸, resolution of albuterol, O, O＇-diaryzoyltartaric acids, parallel resolution, family resolution
中文摘要：

由一系列 O 组成的一个图书馆， O-diaryzoyl-L-(-) 酒石的酸(2 ) 被设计并且综合。2 的芳香的戒指上的取代者显著地影响 diastereomeric 过量和外消旋的 albuterol (1 ) 的分辨率的效率。优秀解决试剂 2a 经由平行途径为 rac-1 的分辨率被选择。然而，三解决的试剂的一个家庭没能改进 rac-1 的分辨率效率。

英文摘要：

A library consisting of a series of O, O＇-diaryzoyl-L-（-）-tartaric acids （2） was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol （1）. Excel- lent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However, a family of three resolving reagents failed to improve the resolution efficiency of rac-1.

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,美国数学评论（网络版）,美国工程索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:81792