中文摘要：

目的：建立鸦胆子油自微乳溶出度的测定方法。方法：采用气相色谱法测定鸦胆子油中油酸的含量，以确定鸦胆子油自微乳化制剂溶出度测定的最佳条件。色谱条件为DB—FFAP毛细管柱（0．25mm×30m，0．25μm），进样口温度220℃，检测器温度220℃，柱温205℃，进样量1μL。以0．1mol·L^-1HCl为溶出介质，硬胶囊壳为载体，转篮法测定鸦胆子油自微乳化给药系统的体外溶出度。结果：鸦胆子油自微乳累积溶出度在15min达90％。结论：该测定方法准确可靠，可用于鸦胆子油自微乳的质量控制。

英文摘要：

Objective： To establish determination method of in virto release of Brucea javanica oil self- microemulsion. Method： The content of oleic acid from B. javanica oil was determined by GC method, to determine optimum conditions of dissolution determination of B. javanica oil self-microemulsion. Chromatographic conditions were： DB-FFAP capillary column （0.25 mm × 30 m, 0.25 μm） , column temperature of 205 ℃ , temperture of inlet and detector were 220 ℃, sample volume 1 μL. 0. 1 mol · L^-1 HC1 as dissolution medium, hard capsule shell as a carrier, in vitro release of B. javanica oil self-microemulsion drug delivery system was determined by rotating basket method. Result： Cumulative dissolution of B. javanica oil self-microemulsion was 90% in 15 min. Conclusion： This determination method was accurate and reliable, and it could be used for quality control of B. javanica oil self-microemulsion.