中文摘要：

采用细菌纤维素（bacterial cellulose,BC）为药物载体,布洛芬为模式药物制备药物缓释体系,体外考察BC膜对药物释放的延缓作用及透皮特性.结果证明：与市售芬必得药片相比,BC膜能够明显减缓药物的释放;药物缓释的机制是纤维素骨架溶胀和药物分子与纤维素链的氢键解离的双重作用.通过筛选促透剂可知,丙二醇促进药物透过BC膜的效果最好;与市售布洛芬凝胶相比,药物以缓慢而恒定的速度释放,既避免了短时间释放高浓度药物对皮肤造成刺激,又可以调节药物的生物利用度,因此以BC膜作为透皮制剂载体更有优势.

英文摘要：

Bacterial cellulose （BC） was used as the carrier for ibuprofen to produce a controlled release system. Drug release studies and transdermal experiments were carried out in vitro to study its sustained release and transdermal properties. The results showed that： carrier BC could significantly extend the drug release time compared with commercially available ibuprofen tablets; mechanism of drug release was the dual role of the cellulose backbone swelling and the hydrogen between drug molecules and cellulose chains. By screening penetration enhancers, propylene glycol was the best one for promoting drug through BC membrane. As a transdermal formulation carrier, BC released drug at a slow and constant speed, which could both avoid skin stimulation caused by the high concentration of drugs released in a short time, and adjusted the bioavailability of the drug. Therefore, BC had great advantage compared with commercially available ibuprofen gel.