中文摘要：

目的：探讨非酒精性脂肪性肝病（NAFLD）与心血管疾病（CVD）的关系。方法根据CT检查结果将研究对象分为NAFLD患者（48例）和健康人（43例），超声测定外周血管硬化和颈动脉内膜中层厚度（IMT）等相关指标，检测生化和内皮舒张功能指标，心脏CTA检测冠状动脉粥样病变。结果 NAFLD患者可溶性细胞间黏附分子-1[sICM-1，（185.1±36.2）ng/ml]、血内皮素-1[ET-1，（104.8±19.3）pg/ml]和臂踝脉搏波速度[baPWV，（15.5±2.3） cm/s]显著高于健康人（85.4±17.3）ng/ml、（67.5±12.1）pg/ml和（13.6±2.4）cm/s，（P＜0.05），而肱动脉血流介导的内皮依赖性舒张功能[FMD，（8.1±2.4）%]明显低于健康人（13.2±3.5）%，（P＜0.05）；此外，NAFLD患者颈动脉IMT厚度（1.31±0.35）mm、劲动脉（31.3%）和冠状动脉粥样斑块检出率（35.4%）均明显高于对照组（0.76±0.18）mm、9.3%和11.6%，（P＜0.05）；Pearson相关分析显示NAFLD分别与IMT、劲动脉和冠状动脉粥样斑块检出率显著正相关（P＜0.01）。结论 NAFLD与CVD密切相关，NAFLD患者可能存在血管内皮功能障碍，应定期进行IMT和粥样斑块检测。

英文摘要：

Objective To investigate the risk factors of cardiovascular disease in patients with nonalcoholic fatty liver disease （NAFLD）. Methods Forty-eight patients with NAFLD and forty-three healthy persons were in-cluded in this study. The NAFLD was diagnosed by computed tomography. Ultrasound was taken for intimal medi-al thickness （IMT）and carotid atherosclerotic plaque examination. The clinical and biochemical features,endothelial function and coronary atherosclerotic plaque examination were also analyzed. Results The levels of sICM-1,ET-1 and baPWV in NAFLD group（185.1±36.2）ng/ml,（104.8±19.3）pg/ml and（15.5±2.3）cm/s were higher than those （85.4±17.3）ng/ml,（67.5±12.1）pg/ml and （13.6±2.4）cm/s,（P〈0.05）,while the FMD level （8.1±2.4）%was lower than that （13.2±3.5%）,（P〈0.05）in the healthy persons;In addition,the IMT （1.31±0.35）mmand the prevalence of patches in carotid（31.3%）and in coronary artery（35.4%）in patients with NAFLD increased than in healthy per-sons （0.76±0.18）mm,9.3% and 11.6%,（P〈0.05）. Conclusion NAFLD is closely associated with cardiovascular disease. The patients with NAFLD might have vascular endothelial dysfunction,and they might be checked-up for early evaluation of vascular atherosclerosis.