中文摘要：

Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been used to treat a variety of hematologic malignancies and non-malignant diseases.Hematopoietic stem cell donor selection is based on identical human leukocyte antigen (HLA) related or unrelated donor matching with the recipient.Donor-recipient HLA mismatching has been associated with graft-versus-host disease (GVHD),increased mortality and decreased disease free survival (DFS).1 Not all patients are able to find a suitable donor,as no more than 25％ of patients have an HLA-identical sibling.Much effort has been devoted to the establishment of bone marrow (BM) registries for HSCT.

英文摘要：

Allogeneic hematopoietic stem cell transplantation （alloHSCT） has been used to treat a variety of hematologic malignancies and non-malignant diseases.Hematopoietic stem cell donor selection is based on identical human leukocyte antigen （HLA） related or unrelated donor matching with the recipient.Donor-recipient HLA mismatching has been associated with graft-versus-host disease （GVHD）,increased mortality and decreased disease free survival （DFS）.1 Not all patients are able to find a suitable donor,as no more than 25% of patients have an HLA-identical sibling.Much effort has been devoted to the establishment of bone marrow （BM） registries for HSCT.Keywords：human leukocyte antigen; transplantation; donor; genotyping