基因传染病学研究象成双的研究那样,研究提供了的肝炎 B (HBV ) 感染研究和种族差别聚类家庭招待基因因素玩的证据在决定 HBV 感染的结果的一个重要角色。开的问题包括基因在感染是哪个人重要的并且怎么发现他们。尽管很多研究寻求了在 HBV 感染 / 坚持和基因多型性之间的基因协会,候选人基于基因的途径清楚地是不适当的充分解释疾病的基因基础。与新基因标记和自动化 genotyping 的来临,基因印射能被进行极其快速。这条途径在某传染病是成功的。连接分析能发现主人基因易受影响到 HBV 并且具有大临床的重要性。
Genetic epidemiology researches such as twin studies, family-clustering of hepatitis B virus (HBV) infection studies and ethnic difference studies have provided the evidence that host genetic factors play an important role in determining the outcome of HBV infection. The opening questions include which human genes are important in infection and how to find them. Though a number of studies have sought genetic associations between HBV infection/persistence and gene polymorphisms, the candidate gene-based approach is clearly inadequate to fully explain the genetic basis of the disease. With the advent of new genetic markers and automated genotyping, genetic mapping can be conducted extremely rapid. This approach has been successful in some infectious diseases. Linkage analysis can find host genes susceptible to HBV and is of great clinical importance.