中文摘要：

microRNA是血管再生重要的调控因子,主要作用于转录后水平的调控。其中,miR-200b对糖尿病慢性创面血管再生的负调控作用研究日益深入。目前已知其作用靶点包括Ets-1、VEGF、VEGFR1、VEGFR2和GATA蛋白等。

英文摘要：

microRNA,the regulator with main effects at transcription level,plays a privotal role on angiogenesis,and the negative regulation of miR-200 b on angiogenesis in chronic wound of diabetes patients is deeply studied.Targets presently known include miR-200 b cover Ets-1,VEGF,VEGFR1,VEGFR2,GATA proteins and so on.