中文摘要：

背景：电化学治疗是治疗肿瘤的一种新的而有效的工具。这种技术非常容易控制和操作，而且对正常组织副作用小。特别对治疗浅表肿瘤非常有效。在电化学治疗治疗过程中，电磁脉冲参数的选取与构成是非常关键的。 目的：利用电化学治疗植入S-180肉瘤的昆明鼠，获得电磁脉冲治疗的最佳参数。 单位：四川大学电子信息学院无线电物理教研室。 设计：随机分组设计、对照实验。 材料：实验于2003-01／2004-05在四川大学生命科学学院细胞实验室完成。选择昆明鼠106只随机分为12组，电压500V、脉冲数为5、电容分别为6，10，14μF组各9只，电压700V、脉冲数为5、电容分别为6，10，14μF组各9只，电压900V、脉冲数为5、电容分别为6，10，14心组各9只，电压700V、电容10μF、脉冲数分别为7，9组各8只，对照组9只。 方法：博来霉素多点腹腔注射入肿瘤块（0．04mg／只），用针状辐射器加上电磁脉冲，每隔2d治疗1次，共3次，18d以后处死小鼠。照射前和照射后第10，18天，测量肿瘤体积，公式为肿瘤体积（mm^3）=3．14159×长×宽×高／6。抑制率（％）=（对照组平均肿瘤体积-照射后平均肿瘤体积）／对照组平均肿瘤体积×100％。相对生长速率：照射后肿瘤体积／照射前肿瘤体积。 主要观察指标：肿瘤体积；抑制率；相对生长速率。 结果：纳入动物106只，均进入结果分析。①当电容是6μF，脉冲数是5而电压变化时[以第10天为例，电压为500，700，900V时肿瘤体积分别为（66．99±91．17）．（62．58±71．83），（78．43±73．91）mm^3]，电压700V时总体效果最好，而电压900V时总体效果较差。②当电压和脉冲数固定而电容变化时（以电压700V，脉冲数为5为例，电容为6，10，14μF时肿瘤抑制率分别为92．14％，90．90％，84．97％），电容6μF时效果最好，电容14μF时效果?

英文摘要：

BACKGROUND：Electrochemotherapy（ECT） is a new and an efficient approach for the treatment of tumor. The technique is very easy to control and operate and is of little harm to normal tissue. Especially, it is very efficient in curing the superficial tumors. In the treatment process of ECT, the selection and constitute of electromagnetic impulse are the key factors. OBJECTIVE： To use the ECT as a therapeutic method for S-180 sarcomas in Kunming mice and obtain the optimal parameters of electromagnetic impulse in curing. SETTING： Department of Wireless Physics, College of Electronics-Information, Sichuan University DESIGN： Random grouping design and controlled experiment study MATERIALS： This experiment was conducted at the Laboratory of Cells, College of Life Sciences, Sichuan University from January 2003 to May 2004. Totally 106 Kunming mice were randomly divid- ed into 12 groups： voltage 500 V, pulse number 5 and capacitance 6, 10 and 14μF, respectively in 3 groups, with 9 mice in each group; voltage 700 V, pulse number 5 and capacitance 6,10 and 14μF, respectively in 3 groups, with 9 mice in each group; voltage 900 V, pulse number 5 and capacitance 6,10 and 14 ttF, respectively in 3 groups, with 9 mice in each group; voltage 700 V, capacitance 10 μF, pulse number 7 and and 9 respectively in 2 groups , with 8 mice in each group , and control group with 9 mice in it. METHODS： The treatment includes injection of Bleomycin 0.04 nag per one （intraperitoneal injecting into tumors through multiple points）, followed by application of electromagnetic impulse using the needles. The treatment was taken every three days and three times in total. Mice were euthanized 18 days later. Tumor volume was measured before irradiation and 10 and 18 days after irradiation. Tumor volume （mm^3）=3.141 59xlengthxwidthx height/6.Inhibitory rate（%）=（average tumor volume of the control groupaverage tumor volume after irradiation）/average tumor volume of control groupxl00%. The relative growth velocit