The instability of climate in Minqin desert area during the process of global warming was analyzed based on meteorological data during 1961 -2013. The results show that the instability of monthly average temperature in January and April increased. Isothermal date in February was10.36 d earlier from 1961 to 2013. The instability of extreme maximum temperature in December and January enhanced. The instability of extreme minimum temperature in July increased. The coefficient of variation of extreme minimum temperature in May was up to 287.3%. The instability of average precipitation in January enhanced. At the same time, the stability of annual average precipitation increased. The stability of climate is more worthy of attention.