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以生物合成为基础的红霉素A的产量提高和结构改造
  • ISSN号：1000-3061
  • 期刊名称：生物工程学报
  • 时间：2015.2
  • 页码：939-954
  • 分类：TQ465.5[化学工程—制药化工]
  • 作者机构：[1]中国科学院上海有机化学研究所湖州生物制造创新中心,浙江湖州313000
  • 相关基金：国家自然科学基金（Nos.81302674,31430005,91213303,91413101）资助
  • 相关项目：硫肽非天然氨基酸衍生探针的生物合成及应用研究
作者： 陈单丹|吴杰群|刘文|
关键词： 红霉素, 生物合成, 产量提高, 结构改造, erythromycin, biosynthesis, production improvement, structure modification
中文摘要：

红霉素A是一种广谱大环内酯类抗生素,在临床上应用广泛。其生物合成包括由聚酮合酶催化的十四元环骨架形成,以及羟基化、糖基化、甲基化后修饰。基于对红霉素A生物合成机制的认识,可以对产生菌种进行定向的遗传操作,达到产量提高和结构改造等目的。本文综述了近年来在红霉素A高产菌株改造和化学结构衍生方面所取得的研究进展,为相关研究人员提供参考。

英文摘要：

Erythromycin A is a clinically important macrolide antibiotic with broad-spectrum activity. Its biosynthesis involves the formation of the 14-membered skeleton catalyzed by polyketide synthases, and the modification steps such as hydroxylation, glycosylation and methylation. Based on the understanding of the biosynthetic mechanism, it is reliable to genetically manipulate the erythromycin A-producing strain for production improvement and structure modification. In this paper, we reviewed the progress regarding erythromycin A in high-producing strain construction and chemical structure derivation, to provide insights for further development.

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期刊信息
  • 《生物工程学报》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国科学院微生物研究所 中国微生物学会
  • 主编：杨胜利
  • 地址：北京市朝阳区大屯路中国科学院微生物研究所内B401室
  • 邮编：100101
  • 邮箱：cjb@im.ac.cn
  • 电话：010-64807509
  • 国际标准刊号：ISSN：1000-3061
  • 国内统一刊号：ISSN：11-1998/Q
  • 邮发代号:82-13
  • 获奖情况:
  • 北京市优秀科技期刊期刊奖,中国科协首届优秀学术期刊奖,2000年中科院优秀科技期刊二等奖
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,波兰哥白尼索引,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:18441