中文摘要：

目的探索遗传因素在双生子儿童心理健康发育中的作用,进行不同版本发育和健康状况评定（develop-ment and well-bing assessment,DAWBA）的效度研究。方法分为同卵双生组（MZ）与异卵双生组（DZ）。利用DAWBA教师版及父母版对双生子儿童所在班级老师及父母进行双生子心理健康状况的调查。并用Kappa系数分析DAWBA教师版与父母版数据的一致性。结果双生子情绪症状（rMZ=0.549,P=0.000;rDZ=0.263,P=0.146）,多动症状（rMZ=0.667,P=0.000;rDZ=0.116,P=0.528）,行为症状（rMZ=0.777,P=0.000;rDZ=0.153,P=0.403）,抽动症状（rMZ=0.552,P=0.005;rDZ=-0.046,P=0.801）,进食症状（rMZ=0.798,P=0.000;rDZ=-0.058P=0.780）,其他关注症状（rMZ=0.491,P=0.011;rDZ=0.327,P=0.068）;MZ组的相关系数明显大于DZ组。一致性检验显示分离性焦虑症状影响（Kappa=0.004）,多动症状（Kappa=0.063）,惊恐症状（Kappa=-0.007）,其他关注症状（Kappa=0.000）,DAWBA教师版与父母版不完全一致。结论遗传在双生子儿童心理健康发育中有一定程度的作用,不同DAWBA版本对研究遗传因素对双生子儿童心理健康发育的影响有较好的效度。

英文摘要：

Objective To explore the validity of the teacher assessment and parent assessment of development and well-bing assessment（DAWBA） for the genetic factors on mental health status in child twins.Methods A total of 93 twins at the age of 6 to 16,growing in a same family and same school were subjected in this study.Short tandem repeat DNA markers were used to identify monozygotic twins（MZ） and dizygotic twins（DZ）.The teacher assessment and parent assessment of Chinese version were investigate on twins’ teachers and parents.Kappa analysis was used to analyze the concordance between the teacher assessment and the parent assessment of DAWBA.Results There were 50 MZ and 43 DZ in this study.The result of the DAWBA in teacher assessment showed that emotions disorder symptom（rMZ=0.549,P=0.000;rDZ=0.263,P=0.146）,hyperactivity symptom（rMZ=0.667,P=0.000;rDZ=0.116,P=0.528）,conduct disorder（rMZ=0.777,P=0.000;rDZ=0.153,P=0.403）,Tourette syndrome/tics（rMZ=0.552,P=0.005;rDZ=-0.046,P=0.801）,anorexia（rMZ=0.798,P=0.000;rDZ=-0.058,P=0.780）,other concerns（rMZ=0.491,P=0.011;rDZ=0.327,P=0.068） and the correlation coefficient of MZ twins was more remarkable than those of DZ twins.Kappa analysis showed that the influence of the intrapair correlation coefficiency of emotional disorder（Kappa=0.004）,hyperactivity disorder（Kappa=0.063）,panic disorder（Kappa=-0.007）,and other concerns（Kappa=0.000）.The teacher and the parent assessment of DAWBA was not complete consistent.Conclusion Genetic factors play a vital role in child twins’ mental health growth.However,the result of their effects on mental health growth is not complete consistent through different assessment of DAWBA.