中文摘要：

聚羟基脂肪酸酯（PHAs）是原核微生物在营养物质缺乏的情况下,作为储备碳源而在细胞内存储的聚合脂类物质,因其与普通塑料物理化学性质相近且具有良好的降解性和生物相容性等特性,可节约石化资源,成为生物合成可降解材料研究的热点.近年来大量研究表明,利用市政污泥的混合菌群合成PHA可以大幅降低成本,有利于PHA合成产业化发展及废物资源化利用.本文总结了利用活性污泥合成PHA工艺中产PHA混合菌群富集阶段和PHA合成阶段的相关研究进展.阐明PHA菌群的筛选阶段工艺（从厌氧-好氧交替模式到好氧动态排水模式）和PHA积累的工艺过程（从批次实验到连续流）;重点阐述合成PHA的富集和积累阶段给料模式的工艺优化;并对合成PHA工艺研究的新思路及现有PHA合成工艺的动力学模型进行了总结.基于现有混合菌群合成PHA方法的研究进展,对未来PHA的研究方向提出建议和展望.

英文摘要：

Polyhydroxyalkanoates （PHA） are biopolymers which can be accumulated by prokaryotic microorganism as intracellular reserve carbon source in the absence of nutrients resource. PHA, being the potential substitute of the conventional plastics due to their similar physical and chemical properties as those petroleum-based traditional plastic as well as good degradability and biocompatibility, would save fossil resources and hence became a hotspot in the biosynthesis of degradable materials research field. Numerous studies in recent years proved that the activated sludge with mixed microbial culture can significantly reduce the costs of PHA synthesis, and further beneficial to the industrialization of PHA synthesis and wastes reclamation. This paper systematically summarized the research progress of activated sludge-based PHA synthesis in the enrichment and accumulation phase, illustrated the PI-IA enrichment bacteria selection process （from AN/AE mode to aerobic dynamic discharge mode） and accumulation phase （from fed-batch to continuous feeding mode）, and emphasized the feeding mode optimization on the PHA enrichment and accumulation phase. Meanwhile, new ideas of research on PHA synthesis and the dynamic model of PHA synthesis were summarized. The paper also proposed some suggestions for the future research focus on the PHA production based on recent research progress on PHA synthesis with mix culture method.