中文摘要：

对壳聚糖进行O-季铵化改性,并与羧甲基-β-环糊精在均相条件下进行缩合反应,制得O-季铵化壳聚糖固载环糊精（QCSCD）,用FTIR、EA和SEM对产物进行表征。以酮洛芬为模型药物,研究其载药及药物释放行为。结果表明,季铵盐基团的引入提高了QCSCD的载药量,为3.97mg/mg,并且改变了QCSCD的pH响应性能。与壳聚糖固载环糊精相反,QCSCD在模拟胃液中的释放速率很快,而在模拟肠液中具有缓释性能。

英文摘要：

O-quarternary ammonium chitosan bearing carboxymethyl-β-cyclodextrin（QCSCD）was synthesized by grafting carboxymethyl-β-cyclodextrin onto O-quarternary ammonium chitosan in the presence of EDC and NHS.The structure of QCSCD was characterized by FTIR,EA and SEM.Using ketoprofen（KP）as a model drug,the release behavior of QCSCD in mimic gastric and intestinal solutions was investigated in comparison with that of chitosan bearing cyclodextrin（CSCD）.Experimental results indicated that QCSCD showed a higher drug-loading capacity with the maximum ketoprofen adsorption of 3.97 mg/mg.Compared with CSCD,QCSCD behaved an opposite pH responsibility and represented more stable release of the entrapped ketoprofen in mimic intestinal solution.These results suggested that QCSCD could be used as a potential biodegradable delivery system for controlled release of hydrophobic drugs with pH-responsive capability.