中文摘要：

肿瘤 angiogenesis 是在肿瘤的血管的不受管束的生长，服务供应营养素和氧，并且移开新陈代谢的浪费。Kaposi 的肉瘤(KS ) ，纺锤形细胞增长描绘的多焦点的 angioproliferative 混乱， neo-angiogenesis，发炎，和浮肿，被 Kaposi 的联系肉瘤的疱疹病毒(KSHV ) 与感染联系。最近的研究显示 KSHV 感染直接由导致 pro-angiogenic 和支持 inflammatory cytokines 通过自分泌和副分泌机制支持 angiogenesis 和发炎。许多也在 KS 损害这些 cytokines 被表示，含有在这恶意的致病的 KSHV 的一个直接角色。几 KSHV 基因涉及导致 KSHV 的 angiogenesis。这些研究提供了卓见进 KS 的致病，并且为这恶意识别了潜在的治疗学的目标。

英文摘要：

Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors, serving to supply nutrients and oxygen, and remove metabolic wastes. Kaposi＇s sarcoma （KS）, a multifocal angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema, is associated with infection by Kaposi＇s sarcoma-associated herpesvirus （KSHV）. Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines. Many of these cytokines are also expressed in KS lesions, implicating a direct role of KSHV in the pathogenesis of this malignancy. Several KSHV genes are involved in KSHV-induced angiogenesis. These studies have provided insights into the pathogenesis of KS, and identified potential therapeutic targets for this malignancy.