中文摘要：

[目的] 研究母鼠金雀异黄素干预对雄性子代大鼠肥胖的影响。[方法] 选用性成熟雌性大鼠，受孕后在孕期及哺乳期间均给予不同剂量的金雀异黄素干预，并设立对照组。干预组母鼠采用添加金雀异黄素的饲料喂饲，剂量分别为3 600、1 200、400 mg/kg。子鼠断乳后采用未添加金雀异黄素的饲料喂饲，直至8周末。实验期间每周观察雄性子鼠的体重；实验结束后测定大鼠身长计算Lee＇s指数，留取脂肪组织，计算脂肪脏器系数，分离血清进行血脂、血糖、胰岛素和炎性因子的检测。[结果] 实验8周末，与对照组相比：3 600 mg/kg组子鼠体重降低（P=0.028）、高密度脂蛋白升高（P=0.038），3 600 mg/kg组和1 200 mg/kg子鼠组Lee＇s指数、总脂肪湿重、血糖水平降低（P=0.031，P=0.049；P=0.009，P=0.016；P=0.033，P=0.026）。实验组子鼠胰岛素、炎性因子未发生明显变化。[结论] 孕期及哺乳期金雀异黄素干预，可以降低雄性子鼠肥胖的发生。

英文摘要：

[Objective] To examine the potential effect of maternal genistein intervention on obesity of male offspring rats.[Methods] Mature female rats were given different doses of genistein （3 600, 1 200, and 400 mg/kg feed, respectively） during pregnancy and lactation. A control group fed without genistein was set up. Offspring rats after weaning were fed no-genistein diet for eight weeks. The body weight of male offspring rats was observed once a week during the experiment. Lee＇s index and ratio of fat/body weight were calculated after the experiment. Blood lipid, blood glucose, insulin, and inflammatory factors in serum samples were detected.[Results] After eight weeks, compared with the control group, the male offspring rats following maternal 3 600 mg/kg genistein treatment showed reduced body weight （P=0.028） and increased high-density lipoprotein cholesterol （P=0.038）; those following maternal 3 600 mg/kg and 1 200 mg/kg genistein treatment showed decreased Lee＇s index, total wet weight of fat, and blood glucose （P=0.031, P=0.049; P=0.009, P=0.016; P=0.033, P=0.026）. No obvious changes in insulin and cytokines were found in the offspring rats with maternal genistein treatment.[Conclusion] Maternal genistein intake during pregnancy and lactation could reduce the occurrence of offspring obesity.