中文摘要：

目的探讨血尿酸、hs CRP及NT-pro BNP在慢性心力衰竭（心衰）诊断方面的临床价值。方法选取41例慢性心衰患者及31例健康对照组,检测外周血尿酸、hs CRP及NT-pro BNP的浓度,分析其与NYHA（纽约心脏病协会）心功能分级、LVEF（左室射血分数）及LVEDD（左室舒张末期内径）的相关性。结果慢性心衰患者血尿酸、hs CRP及NT-pro BNP较对照组显著升高（P〈0.05）,不同心功能分级之间的血尿酸及NT-pro BNP亦有统计学差异（P〈0.05）。尿酸及NT-pro BNP与心功能分级及LVEDD呈正相关（r=0.67,P〈0.05;r=0.52,P〈0.05;r=0.54,P〈0.05;r=0.53,P〈0.05）,与LVEF呈负相关（r=-0.61,P〈0.05;r=-0.57,P〈0.05）。尿酸与NT-pro BNP两者之间亦有一定的相关性（r=0.46,P〈0.05）。结论慢性心衰患者血尿酸及NT-pro BNP与疾病严重程度相关,是心功能评价的较好指标,而hs CRP在心衰诊断的临床价值不如尿酸及NT-pro BNP。

英文摘要：

OBJECTIVE To investigate the clinical significance of the serum uric acid,NT-pro BNP and hs CRP in patients with chronic heart failure. METHODS The serum levels of uric acid,NT-pro BNP and hs CRP were measured in 41 patients with chronic heart failure and 31 cases of healthy people. Then the potential correlation correlation between cardiac function classification（ New York heart disease association）,LVEF（ left ventricular ejection fraction）,LVEDD（ left ventricular end diastolic diameter） and the serum indicators was analyzed. RESULTS Our results revealed that serum uric acid,NT-pro BNP and hs CRP were significantly higher in heart failure patient（ P 0. 05）. Uric acid and NT-pro BNP were increased with increasing cardiac function classification（ P 0. 05）. In all subjects,uric acid and NT-pro BNP were correlated with cardiac function classification and LVEDD（ r = 0. 67,P 0. 05; r = 0. 52,P 0. 05; r = 0. 54,P 0. 05; r = 0. 53,P 0. 05）. Uric acid and NT-pro BNP were correlated with LVEF negatively（ r =- 0. 61,P 0. 05; r =- 0. 57,P 0. 05）. Uric acid were also correlated with NT-pro BNP（ r =0. 46,P 0. 05）. CONCLUSION Serum uric acid and NT-pro BNP were related to disease severity in chronic heart failure,and may be better indicators in cardiac function evaluation. But the clinical value of hs CRP in the diagnosis of heart failure was inferior to uric acid and NT-pro BNP.