中文摘要：

目的研究广西扶绥地区乙型肝炎（简称乙肝）患者HBV基因型分布特点,为本地区乙肝的防治及临床抗乙肝感染的治疗提供依据。方法采用巢式PCR技术对285例（肝癌40例,乙肝病毒携带者245例）扩增HBV S区基因,经测序后与标准序列比对,得出相应的基因型,分析HBV基因型的分布概况及其特点。结果在285例患者中,B基因型59例（20.7%）,C基因型223例（78.2%）,未分型3例（1.1%）。在肝癌和乙肝病毒携带者中,B基因型、C基因型分别为10例（25.00%）、30例（75.00%）和49例（20.25%）、193例（79.75%）（P〉0.05）;男性B基因型、C基因型分别为40例、158例,女性B基因型、C基因型分别为19例、65例,HBV基因型在男性和女性间的分布差异均无统计学意义（P均〉0.05）;在〈30岁、30~40岁、40~55岁、〉55岁各年龄组间HBV基因型的分布差异均无统计学意义（P均〉0.05）。结论扶绥地区HBV基因型以C基因型占主要优势,其次是B基因型,未见其他分型;HBV基因型在年龄、性别间的分布无明显差异。

英文摘要：

Objective To study the genotype distribution of hepatitis B virus （HBV） in patients from the Fusui area of China in order to guide prevention and treatment efforts. Methods A total of 40 patients with liver cancer and 245 HBV carriers were analyzed using nested PCR to amplify the HBV S region. The amplicons were sequenced and analyzed in sequence alignments with published HBV genotypes. Result Of the 285 participants,59 （20.7%） were infected with genotype B virus,223 （78.2%） with genotype C,and 3 （1.1% ） with an undefined genotype. Of the 282 participants with either genotype B or C virus, men accounted for 40 with genotype B and 158 with genotype C;women accounted for 19 with genotype B and 65 with genotype C. The gender distribution was similar for these two genotypes （P〉0.05）. Among liver cancer patients, 10 （25%） had genotype B and 30 （75%） had genotype C;among HBV carriers ,49（20.25%） had genotype B and 193（79.75%） had genotype C. Stratification of patients into four age groups （〈30 years, 30-40 years, 40-55 years,and 〉55 years）,The distribution of these two genotypes was similar in the four age groups（P〉0.05）. Conclusion HBV genotype C predominates in the Fusui area,followed by genotype B ,with no other types observed. Genotypes B and C are distributed similarly among individuals of different age and gender.