中文摘要：

目的观察中药复方柴红方治疗黄褐斑的临床疗效及其对性激素水平的影响。方法将150例患者随机分为两组,治疗组100例和对照组50例,治疗组口服柴红方,对照组口服维生素C片。两组均以4周为1个疗程,疗程结束后,肉眼观察患者治疗前后色斑面积、颜色等的变化,测定月经前1周血清卵泡刺激素（FSH）、黄体生成激素（LH）、雌二醇（E2）及孕酮（P）水平。结果治疗组临床总有效率86.6%,对照组总有效率49.0%,两组比较,差异有统计学意义（P〈0.01）,提示治疗组疗效优于对照组。治疗组治疗后LH和E2水平较治疗前明显降低（P〈0.05）,对照组治疗前后FSH、P、LH、E2水平变化不明显（P〉0.05）。治疗后两组LH、E2比较,差异有统计学意义（P〈0.05）。结论柴红方治疗黄褐斑患者临床疗效确切,其药理机理可能与其调节患者性激素水平有关。

英文摘要：

Objective To observe the clinical efficacy on chloasma treated with compound chaihong formula and its influence on sex hormone levels.Methods 150 cases were divided randomly into a treatment group（100 cases）and a control group（50 cases）.In treatment group,oral administration of chaihong formula was applied.In control group,oral administration of vitamin C tablet was given.The cases of either group were treated for 4 weeks as 1 session.At the end of treatment session,the changes in pigmentation size and color were observed with naked eyes and compared with those before treatment.The levels of serum follicule stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2）and progesterone（P）were detected 1 week before menstruation.Results The total effective rate was 86.6% in treatment group and was 49.0% in control group,indicating statistical significant difference in comparison（P0.01）.It was suggested that the efficacy in treatment group was superior to that in control group.In treatment group,the levels of LH and E2 after treatment were lower as compared with those before treatment（P0.05）.In control group,there were no obvious changes in FSH,P,LH and E2 before and after treatment（P0.05）.The levels of LH and E2 after treatment were significantly different in comparison of two groups（P0.05）.Conclusion Chaihong formula achieves a definite efficacy on chloasma in clinic and its pharmacological mechanism may be relevant with its regulation on sex hormone levels for the patients.