中文摘要：

目的：建立毛支清口服液中甲基正壬酮的含量测定方法。方法：采用气相色谱法。Rtx-1毛细管色谱柱（0．25mm×30m，0．25μm），FID检测器，柱温80℃（2min），以10℃·min。升至220℃，再以20qC·min。升至270oC；进样口温度240cc，检测器温度280℃，进样量1止，分流比30：I，载气为氮气，柱流量1．13mL·min^（-1），空气流量400mL·rain^（-1）；氢气流量40mL·min^（-1）。结果：甲基正壬酮进样浓度为0．0321～0．6416g·L11时与峰面积呈良好的线性关系，回归方程为Y=3．00x10^6x-19844（r=0．9998），平均回收率97．76％，RSD1．82％。结论：所建立的气相色谱方法简便、准确、灵敏度高、重复性好，可作为毛支清口服液的质量控制标准。

英文摘要：

Objective： To establish an method for determination of methyl nonyl ketone in Maozhiqing Oral Liquid. Method： The methyl nonyl ketone was determined by gas chromatography with Rtx-1 capillary chromatographic column （0.25 mm x30 m, 0.25 μm）. Column temperature： 80 ℃ for 2 min, increased at 10℃.min-1 to 220 ℃, then 20 ℃·min^（-1） to 270 ℃. Injector temperature： 240 ℃, FID temperature： 280 ℃. Injector volume was 1 μL; Split ratio was 30： 1. Nitrogen was used as carrier gas, the flow of column was 1.13 mL·min-1 Air： 400 mL .min-1 Hydrogen： 40 mL .rain-1 Result： Methyl nonyl ketone has a good linear relationship with the peak area within the range of 0. 032 143.641 6 g ·L-1 with an regression equation being Y = 3.00 × 10^6X - 19 844 （r = 0. 999 8）. The average recovery was 97.76% and the relative standard deviation was 1.82%. Conclusion： The established method of gas chromatography can be used for quality control of Maozhiqing Oral Liquid because of its simplicity, accuracy, high sensitive and good reproducibility.