中文摘要：

托烷类生物碱主要包括阿托品、莨菪碱、山莨菪碱、东莨菪碱和樟柳碱,是主要抗胆碱类药物。解析药用茄科植物托烷类生物碱合成的分子调控机制以及研发高产托烷类生物碱的植物生物反应器一直是近几年的研究热点。该文对近年来国内外有关托烷类生物碱在不同茄科植物中的合成部位、分子调控和利用转基因技术研发高产托烷类生物碱的发根生物反应器的研究进展进行综述,并对可能存在的问题以及应用前景进行了展望。

英文摘要：

Tropane alkaloids,including atropine,hyoscyamine,anisodamine and scopolamine are important anticholinergic drugs.Insight into molecular regulation mechanism of biosynthesis on tropane alkaloids in some Solanaceae herb and developing plant bioreactor to improve tropane alkaloids producing,especially scopolamine is becoming a hot pot in recent years.In this review,we summarized progress on tropane alkaloids biosynthesis tissues,molecular regulation and bioreactor technology.In addition,we discussed some problems in this field and looked forward its development in the future.