新发冠状病毒危害人类和动物健康,造成严重公共卫生问题和巨大经济损失。丁型冠状病毒(Deltacoronavirus)是2009年发现并在2011年正式划分的第四种冠状病毒属,其属内的病毒基因组特征与其他冠状病毒属有较大差异。其中,猪丁型冠状病毒(PDcoV)与近两年爆发的猪病毒性腹泻疫情密切相关。本文以猪丁型冠状病毒为例,从病毒基因组结构、进化、流行情况、检测方法、致病性试验、蛋白质功能等方面介绍其研究进展。
Deltacoronavirus was first identified in 2009, and is classified into the fourth genus in the Coro- naviridae family, showing distinct genomic features from the members of other three coronavirus genera. Porcine deltacoronavirus (PDCoV), is associated with the outbreaks of swine diarrhea in China and the United States in recent two years. This mini-review gives an introduction to recent progress on deltacoronavirus, with an emphasis on PDCoV, including the genomic structure, evolution, detection, epidemiology and pathogenecity.