中文摘要：

去泛素化酶具有逆转泛素化的作用，其大多数研究还保留在分子生物学领域，在转化医学研究中尚未引起充分的重视。目前研究发现，去泛素化酶的目的蛋白通过各种途径影响肿瘤的发生、发展，如细胞凋亡和自噬、炎性反应和肿瘤的关系、肿瘤缺氧、肿瘤信号通路、细胞周期的调节和DNA损伤等。现就去泛素化酶与肿瘤发生、发展的关系及研究进展作一综述。

英文摘要：

Deubiquitinating enzymes, reversing protein ubiquitination, most of the researches focused on the field of molecular biology. However, it have not yet attracted enough attention in translational medicine research. In fact, target proteins of deubiquitinating enzymes affect the tumor progression through various ways, for example, cell apoptosis and autophagy, the link between inflammation and cancer, tumor hypoxia, signal transduction, cell cycle regulation and DNA damage. This paper reviewed the research progress on the relations between deubiquitinating enzymes and the correlated factors of tumor.