中文摘要：

炎性体是一个识别多种固有免疫系统激活物的多蛋白复合体,它可以促进白细胞介素1β（IL-1β）和白细胞介素18（IL-18）等炎症因子的生成,参与多种心血管疾病（CVD）的炎症反应,如动脉粥样硬化、缺血性心脏病、缺血再灌注损伤、高血压和心肌病变等.炎性体激活及其下游产物生成的调控机制已成为CVD研究领域新的热点.此外,炎性体作为固有免疫系统的一部分,为CVD治疗提供了新的药物靶点.

英文摘要：

Inflammasome is a muhi-protein complex sensing a variety of stimuli of the innate immune system. In- flammasome promotes the production of pro-inflammatory cytokines such as interleukin-113 and interleukin-18. The activa- tion of inflammasome is associated with chronic inflammation in various cardiovascular diseases （CVD） such as atheroscle- rosis, ischemic heart disease, ischemia-reperfusion injury, hypertension, and cardiomyopathy. The mechanism of inflam- masome activation and its downstream cytokines production has become a research hotspot in cardiovascular system. In addition, the discovery of inflammasome has expanded our understanding of how the innate immunity disrupts the develop- ment and progression of CVD, and targeting inflammasome provides new avenues for therapy of these diseases.