中文摘要：

目的探讨纤溶酶原激活抑制物-1（PAI-1）基因46／56多态性与儿童青少年血糖及其相关指标的关系。方法选取北京市3919名7～18岁儿童青少年进行身体测量和FPG水平检测，部分样本检测Fins水平。利用基质支持的激光释放／电离飞行时间质谱分析（MALI）I-TDFMS）对PAI-1基因4G／5G多态性进行检测。采用多元线性回归和Logistic二元回归分析基因多态性与血糖及相关指标的关系。结果校正研究人群、年龄和性别后发现，与5G5G基因型比较，4G等位基因携带者FPG水平较高（｜9=0．064，SE=0．029，P=0．025）。4G／5G多态性与IFG有相关性（OR=1．640，95％CI：1．1662．309，P=0．005）。校正BMI后该多态性与IFG的相关性没有变化（FPG：β=0．063，SE=0．029，P=0．029；IFG：OR=1．628，95％CI：1．155-2．293，P=0．005）。结论PAI基因4G／5G多态性与儿童青少年血糖水平和IFG有相关性，其效应独立于BMI的作用。

英文摘要：

Objective To explore the relationship between 4G/5G polyrnorphism in PAI-1 （plasminogen activator inhibitor-1） gene with blood glucose and glucose-related phenotypes in children and adolescents. Methods Total 3,919 children and adolescents aged 7 - 18 years were recruited. Anthropometric measurements and fasting blood glucose （FPG） detection were performed. Fasting insulin levels in a subgroup were detected. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） was used to genotype 4G/SG polymorphism. Linear and logistic regressions were used to analyze the relationship between 4G/SG polymorphism and glucose and related phenotypes. Results Compared with 5G5G genotype,4G allele （4GSG and 4G4G） carriers had higher FPG, after adjustment for age, sex and study population （β= 0. 064, SE= 0. 029, P = 0. 025）. 4G/SG polymorphism was associated with risk of impaired fasting glucose （IFG） （OR= 1. 640,95 % CI： 1. 166 2. 309,P=0. 005）. The above correlation remained unchanged after further adjustment for body mass index （BMI） （fasting g[ucose..fl=0, 063,SE=0. 029,P=0. 029; IFG：OR=1. 628,95%CI：1. 155-2. 293, P= 0. 005 ）. Conclusion 4G/SG polymorphism in PAI-1 gene is associated with FPG and IFG in children and adolescents with its effect independent of BMI.