中文摘要：

目的：综合评价依赖还原型辅酶Ⅰ/Ⅱ醌氧化还原酶1（ N QO1）基因C609 T多态性与肺癌易感性的关系。方法检索中国知网、万方、维普、Medline、Pubmed等数据库，收集有关 NQO1基因多态性与肺癌易感性关系的文献，并剔除不符合要求的文献，然后用 Stata12软件进行分析，计算合计的比值比（OR）及95％可信区间（CI），并评估发表偏倚。结果共有16项病例对照研究纳入分析，与野生纯合基因型（CC）相比，杂合基因型（CT）[OR（95％ CI）＝1．09（0．96～1．24）]以及突变纯合基因型（TT）[OR（95％ CI）＝1．14（0．94～1．39）]均与肺癌的发病风险无统计学意义。分层分析结果显示，在以人群为基础的病例对照研究中携带CT 基因型是肺癌的危险因素，其OR及95％ CI为1．037（1．000～1．075），CT基因型同时也是黄种人患肺癌的危险因素，其 OR值及95％C I为1．039（1．001～1．078）。结论 N QO1 C609 T基因多态性与黄种人肺癌患病风险有关。

英文摘要：

Objective To evaluate the effect of the genetic polymorphism of C609T [NAD（P）H , Quinone oxidoreductase1 ,NQO1 C609T ] on the risk of lung cancer . Methods A total of 16 studies （5 416 cases and 6 486 controls） regarding NQO1 C609T between 1995 and 2014 were identified through researching Medline ,Pubmed ,CNKI ,Wanfang Data ,VIP .A meta-analysis was performed to obtain sum-mary estimated odd ratios （ORs） and 95% confidence intervals（95% CI） of NQO1 C609T for lung cancer . Results There were no significant associations between NQO1 609 CT genotype [adjusted OR （95%CI）= 1 .09（0 .96 ~ 1 .24）] ,as well as NQO1 609 TT genotype [adjusted OR（95% CI）= 1 .14（0 .94~1 .39）] ,and the risk of lung cancer .The stratified analysis showed that the NQO1 609 CT [adjusted OR （95% CI）=1 .037（1 .000~1 .075）] genotype increased the risk of lung cancer in population based case-control study ,as well as in Asian race [adjusted OR（95% CI）=1 .039（1 .001~1 .078）] . Conclusion This meta-analysis failed to confirm the association of NQO1 gene C609T polymorphism with lung cancer risk .