中文摘要：

目的：检测麻黄及麻黄-白术药对提取物中5种麻黄生物碱（NME、NMP、E、PE、ME）的大鼠血浆药动学及组织分布,探讨麻黄配伍白术前后的变化规律。方法：采用HPLC-MS分析方法,ZORBAX SB-C18色谱柱（100 mm×2.1 mm,3.5μm）,柱温：35℃,流动相：乙腈-0.1%甲酸梯度洗脱,流速：0.4 m L/min;正离子MRM检测模式。结果：麻黄与白术配伍后麻黄生物碱在大鼠血浆及组织中的分布趋势均发生一定变化。结论：麻黄配伍白术后,可能起到增加药物疗效,同时又能降低麻黄生物碱毒性的作用。

英文摘要：

Objective： Five kinds of Ephedra alkaloids（NME,NMP,E,PE and ME） in Ephedrae Herba extracts and Ephedrae Herba-Atractylodis Macrocephalae Rhizoma herbal pair extracts of plasma pharmacokinetic and tissue distribution study in rats were carried out,to discuss the changes of Ephedrae Herba compatibility with Atractylodis Macrocephalae Rhizoma before and after. Methods： HPLCMS method was used and the condition was as flollows： ZORBAX SB-C18column（100 mm × 2. 1 mm,3. 5 μm）,column temperature of35 ℃,mobile phase of ACE-0. 1% formic solution in gradient elution mode,flow rate at 0. 4 m L/min; MRM positive ion detection mode. Results： The distribution trends of Ephedra alkaloids were changing in plasma and tissues of rats after Ephedrae Herba compatibility with Atractylodis Macrocephalae Rhizoma. Conclusion： Ephedrae Herba compatibility with Atractylodis Macrocephalae Rhizoma may increase drug efficacy and reduce the toxicity of Ephedra alkaloids at the same time.