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精准医学思维对创伤诊治模式的影响与前景
  • 时间:0
  • 分类:R378[医药卫生—病原生物学;医药卫生—基础医学]
  • 作者机构:[1]第三军医大学野战外科研究所创伤烧伤与复合伤国家重点实验室,重庆400042
  • 相关基金:全军“十二五”重大项目(AWS14C003);国家“973”课题(2012CB518102);国家自然科学基金(81372105,31271242)
中文摘要:

随着现代急救技术和有效药物的运用,创伤患者即刻和早期死亡得到有效控制。然而,循证医学证据表明,创伤患者伤情转归和并发症的防治迄今仍是国际医学界面临的重大挑战。究其原因,创伤救治模式的经验性和普适性对于常规创伤伤情的诊治有重要价值。然而,受社会和机体内外环境因素的制约,创伤患者伤情与转归千差万别,无统一依据可循。因此,现今程序性创伤诊治模式在理念上尚有提升空间。精准医学概念的提出,为创伤诊治开辟了新的视角,是对创伤伤情认识水平在理论上的深化与拓展。在转化医学时代,将创伤基础研究成果有效指导伤员诊治,不仅对创伤精准与个体化诊治具有重要价值,也是在思维层面对创伤诊治从理论-实践-理论循环模式的提升,这对于提升创伤患者诊治水平,促进伤员康复和回归社会有重要临床意义。

英文摘要:

With the usage of advanced techniques in emergency treatment and efficient drugs, the level of trauma care has been improved obviously. The immediate and early mortality is declined in this decade. However, the emerging data from evidence-based medicine show that the outcome of traumatic condition and the treatment of traumatic complications constitute the main challenges in the international medical circles. Actually, although the experience and universality for the patterns of" trauma treatment is valuable for the routine diagnoses and treatments of injured patients, the highly differentiated features of traumatic condition and outcome result in the missing of unified criteria owing to the limitation of social and environmental factors.Thus, we should remain to absorb new paradigm shifting in the diagnosis and treatment patterns of tramna. The concept of precision medicine open up a new visual angle for traumatology. It may ihrther deepen and expand our knowledge of traumatic conditions and individualized new diagnostics and therapeutics in trauma.In the era of translational medicine,it is of great importance to absorb the new ideas of basic researct~ t~n" the precision and individualization in the diagnosis and treatment in traumatology.From the stratification of clinical thoughts, we urgently need to extend and improve our thoughts of diagnosis and treatment options cm,cerning the circles of theory, practice and theory. It is undoubtedly valuable for the improvement of diagnosis and treatment of trauma as well as the rehabilitation and regression towards our society for trauma patients.

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